THE ULTIMATE GUIDE TO SBS88

Some strands of Escherichia coli can have the polyketide synthetase (pks) island that encodes colibactin, a genotoxic compound which can alkylate DNA on adenine residues and induce point mutations with a selected signature12,13 (COSMIC SBS88). On top of that, publicity to pks+ E. coli generates a characteristic small indel signature (COSMIC ID18) w